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Solvent Effects SN2

Chem 240 Videos - Video 22 SN2 reactions are almost always run in very polar, but aprotic solvents. In other words, DMSO, DMF. Acetone, to a lesser degree, but acetone is much more pleasant to work with. In an SN2 reaction, you specifically need to find a way to lower the energy of the transition state WITHOUT also lowering the energy of the starting materials too much. Polar aprotic solvents in the mold of DMSO and DMF fit the bill because they can easily interact with "+", but interact much more poorly with "-", which is precisely what we need.