: LONG-TERM USE OF DOUBLE INTERNAL STENTS FOR EXTRINSIC MALIGNANT URETERAL OBSTRUC скачать в хорошем качестве

: LONG-TERM USE OF DOUBLE INTERNAL STENTS FOR EXTRINSIC MALIGNANT URETERAL OBSTRUC

: LONG-TERM USE OF DOUBLE INTERNAL STENTS FOR EXTRINSIC MALIGNANT URETERAL OBSTRUC To assess long-term outcomes of double internal stents (DIS) for the relief of external malignant ureteral obstruction (MUO). DIS (7F each; 12-month indwelling time) were inserted under general anesthesia in 62 consecutive patients (75 renal units) with MUO during 2007–2018. Surveillance was performed every 3 months, and stents were exchanged routinely every year. The need for permanent stent retrieval was considered stent failure. Maintenance of stent patency and disease-specific survival (DSS) were estimated (Kaplan–Meier). Risk factors were also assessed (univariate and multivariable Cox regression analyses). The median follow-up was 27 months (interquartile range [IQR] 20–27). The most frequent tumors causing obstruction were colorectal and ovarian cancers. Six patients (10%) had stent failure caused by sepsis, creatinine elevation, or hematuria. The average time to failure was 15 months (range 1–27). A history of radiation and an estimated glomerular filtration rate (eGFR) ≤of 45 mL/(min/1.73 m2) were associated with stent failure (p = 0.038 and p = 0.001, respectively). Thirty-nine patients died with a median DSS of 21 months (IQR 8.6-not reached). Multivariate analysis identified eGFR ≤60 mL/(min/1.73 m2) (hazard ratio [HR] 2.1, 95% confidence interval [CI] 1.1–4.2, p = 0.02) and need for balloon dilation (HR 2.1, 95% CI 1.1–4.1, p = 0.02) as independent predictors for disease-related mortality. Twenty-six patients (42%) had stent-related complications, for example, irritative symptoms, hematuria, and infections, of whom only two failed. One-year indwelling DIS provides effective long-term relief of MUO and represents a simple and effective alternative to other methods of urinary diversion. They avoid the need for external tubes and contribute to improved patient satisfaction.