Adenomatous Polyp or Tubular Adenoma With a Focus of Carcinoma Histopathology - Madeformedical.com скачать в хорошем качестве

Adenomatous Polyp or Tubular Adenoma With a Focus of Carcinoma Histopathology - Madeformedical.com

When a tubular adenoma exhibits a focus of carcinoma, it means that within the benign adenomatous tissue, there is a localized area that has transformed into malignant carcinoma. This transition is often referred to as "adenoma to carcinoma sequence" and is a common progression pathway in colorectal cancer. Histopathologically, the features you might observe in a tubular adenoma with a focus of carcinoma include: 1. *Transition zone:* There will be a clear demarcation between the benign tubular adenoma area and the malignant carcinoma area. 2. *Dysplastic changes:* The carcinoma area will show more pronounced cellular atypia, such as larger, hyperchromatic (darkly stained) nuclei, increased mitotic activity, and a higher nuclear-to-cytoplasmic ratio. These changes indicate the presence of malignancy. 3. *Invasion:* Unlike adenomas, where the cells usually remain confined to the glandular structures, the carcinoma focus might show invasion into the surrounding stroma or deeper layers of tissue. 4. *Loss of polarity:* The cellular arrangement might be disorganized in the carcinoma focus, with loss of the normal glandular architecture seen in adenomas. 5. *Potential metastasis:* Depending on the extent of malignancy, there might be indications of the cancerous cells infiltrating blood or lymphatic vessels, suggesting the potential for metastasis. The presence of carcinoma within an adenoma signifies a more advanced stage and higher potential for malignancy. It underscores the importance of early detection and removal of adenomatous polyps during regular screenings to prevent the development of carcinoma.