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(MGB, one anastomosis gastric bypass, single anastomosis gastric bypass, omega looop gastric bypass) A surgical procedure for severely obese patients to lose weight and improve their overall health. Gastric bypass is one of reliable and popular type of bariatric surgery (a form of weight loss surgery). It connects the newly formed gastric pouch to jejunum in a loop fashion anastomosis. Bile and pancreatic enzymes (bilio-pancreatic juices) are not diverted away from the pouch, therefore there is a potential risk of biliary reflux into gastric pouch. (Structures of gastric bypass) • gastric pouch: The stomach's volume is significantly reduced and limit food intake. The restrictive component of bariatric surgery, decreasing the stomach's natural capacity. • intestinal bypass: It allows food to bypass the majority of the stomach, the entire duodenum, and a portion of the jejunum, while still enabling digestive juices from the bypassed stomach and duodenum to mix with the ingested food further down the intestine. The malabsorptive component of bariatric surgery. Nutrients pass through the shortened intestine, less nutrients are absorbed. (Types of gastric bypass) • mini gastric bypass • Roux-en-Y gastric bypass • distal gastric bypass (mini gastric bypass (MGB)) • gastric pouch: A long and narrow pouch, created along the lesser curvature of the stomach, starting near the esophagus and extending downwards. • intestinal bypass: The jejunum is not cut, instead, a loop of the jejunum approximately 200 cm from the start of the small intestine is brought up and connected to the newly formed gastric pouch in a lateral anastomosis. (Roux-en-Y gastric bypass (RYGB)) • gastric pouch: A significantly small pouch, created near the cardia. • intestinal bypass: The jejunum is cut. The distal cut end is brought up and connected to the newly formed gastric pouch. The proximal cut end is connected to the jejunum approximately 200 cm from the start of the small intestine, creating a "Y" configuration. (distal gastric bypass (DGB)) • gastric pouch: Same as RYGB. • intestinal bypass: Similar to RYGB, but the proximal cut end is connected to the jejunum further down, approximately 200 cm from the end of the small intestine. (Comparisons) • Surgical complexity: MGB is simpler than RYGB due to the creation of only one anastomosis. • Risk of bile reflux: MGB has a potentially higher risk because the bile and pancreatic enzymes flow through the same pathway as the ingested food from the outset, whereas RYGB reduces this risk by delaying their mixture. • DGB is the revision of RYGB. Food mixes with digestive juices only in the last 200 cm of the small intestine, resulting in significantly reduced absorption. If patients fail to lose weight with the medical management methods such as RYGB and continue to suffer from obesity, DGB might be an option for them to further lose excess weight and control comorbidity.