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In this video Prof. Jan Hengstler, head of IfADo's toxicology department and liver expert, presents new insight into liver physiology which is relevant to identify efficient therapies. ► In Germany, as many as five million people suffer from liver diseases. But the liver is a resilient and complex organ which we do not understand enough even in its basic functioning, hindering our ability to treat its diseases. A team at the Leibniz Research Centre for Working Environment and Human Factors (IfADo) is now providing fundamentally new insights into the function of the liver to produce bile and transport it through ‘canaliculi’: According to the study, there is a stagnant liquid in these canaliculi and the constituents of bile move in this standing liquid primarily by diffusion. These findings, published in the journal "Hepatology", overturn long-standing assumptions about how the liver secretes bile. ▬ More information ▬▬▬▬▬▬▬▬▬▬▬▬ · Mentioned Hepatology paper: https://doi.org/10.1002/hep.31422 · IfADo website: https://www.ifado.de/ifadoen/?noredir... The study was supported by the German Federal Ministry of Education and Research within the program "Systems Medicine of the Liver (LiSyM)". ▬ About IfADo ▬▬▬▬▬▬▬▬▬▬▬▬ The Leibniz Research Centre for Working Environment and Human Factors (IfADo), under the legal sponsorship of the “Forschungsgesellschaft für Arbeitsphysiologie und Arbeitsschutz e.V.”, investigates the potential and risks of modern work on the basis of life and behavior sciences. The results are used to derive principles for the performance- and health-promoting design of the working environment. For this purpose, around 220 employees are working at IfADo. The research centre is financed by institutional funding from the German federal and state governments as well as from third-party funds (2019 total 14.7 million euros). IfADo is a member of the Leibniz Association, which comprises 96 independent institutions. ► Twitter: @IfADo_info ►Facebook: @IfADo.info