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Different patients respond differently to surgery, but what affects how quickly you recover? Can we tell in advance which patients are going to have complications? New surgical procedures are developed all the time, but how do we test these and how do we know whether a new procedure is better or safer? Researchers in Bristol are trying to answer these questions in the National Institute for Health Research Bristol Biomedical Research Centre (NIHR Bristol BRC). Professor Gianni Angelini, British Heart Foundation Professor of Cardiac Surgery, shares some of his experiences as a cardiac surgeon and the research being carried out in the BRC's Cardiovascular Theme to develop new treatments for cardiovascular disease. Nicola Morris, whose son, Calum, has had a number of major heart operations, talks about their experiences and their hope that research will help children like Calum. Professor Jane Blazeby, Professor of Surgery, speaks about the research in the BRC's Surgical Innovation theme, on how we evaluate and monitor new surgical procedures and whether we really can trust research based surgery.