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The stomach wall exhibits four generel regions: musoca, submucosa, muscularis externa and serosa. The surface of stomach is lined with simple columnar epithelium, that extends into and lines the gastric pits, which are tubular infoldings of the surface epithelium. Beneath the epithelium is lamina propria, loose connective tissue, which fills the space between gastric glands. A thin smooth muscle muscularis mucosar forms the outer border of the mucosa. The gastric glands open into the bottomof the gastric pits. In gastric pits we can recognize acidophilic parietal cells, which produce hydrochlorid acid, and basophilic chief cells, which are filled with granules that contain the proenzyme pepsinogen. The submucosa contains loose connective tisssue with lymph vessels, blood vessels an parasymphathetic ganglia of the submucosal Meissner nerve plexus. The muscularis externa consists of three layers of smooth muscle, each oriented in different direction, an inner oblique, a middle circular, and an outer longitudinal layer. Located between the circular and longitudinal smooth muscle layers is a myenteric (Auerbach) nerve plexus of parasymphathetic ganglia and nerve fibres. The serosa consists of thin layer of connective tissue and is covered by a simple squamous mesothelium of the visceral peritoneum. Stained: hematoxylin-eosin (nuclei of cells are violet, cytoplasm is pink) Author: Mgr. Tereza Blassová, Ph.D. Scaning of the specimen: Mgr. Yaroslav Kolinko, Ph.D.