Pathology of Growth hormone secreting adenoma скачать в хорошем качестве

Pathology of Growth hormone secreting adenoma

Growth hormone-secreting adenomas are pituitary tumors that produce excess growth hormone (GH), leading to conditions like acromegaly and gigantism. These adenomas account for approximately 20% of all pituitary tumors. Pathological Features Histological Variants: Densely Granulated GH Adenomas – Large cells with eosinophilic cytoplasm and abundant secretory granules. Sparsely Granulated GH Adenomas – Chromophobic cells with less prominent granules. Mixed GH & Prolactin Adenomas – Tumors that co-secrete prolactin, leading to hyperprolactinemia. Tumor Growth & Invasion: Most GH-secreting adenomas are macroadenomas at diagnosis. Can cause suprasellar expansion, leading to headaches and visual field defects. Molecular Pathogenesis: Mutations in GNAS gene are commonly associated with GH-secreting adenomas. Pituitary transcription factors influence tumor behavior and hormone secretion. Clinical Implications Elevated GH & IGF-1 levels cause soft tissue overgrowth, metabolic disturbances, and cardiovascular complications. Treatment includes surgical resection, somatostatin analogs, dopamine agonists, and GH receptor antagonists #adenoma