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With the incidence of brain cancer on the rise, clinical trials are a great tool for the investigation of safety and efficacy of various drugs in the human system, with the propensity to prevent and rid patients of disease. Many aspects of this topic should be taken into account including the patients’ perspective, which can often become secondary to the drug’s success or marketability. This video focuses on the importance of clinical trials and resources available to brain cancer patients and their families from the Brain Tumour Foundation of Canada. As indicated by a 2017 study (DasMahapatra et. al), patients are willing to enrol into clinical trials upon receiving detailed information. This video addresses patients’ concerns and provides them with support and research-based knowledge to make an informed decision regarding whether they wish to participate in a clinical trial. This video was made by McMaster Demystifying Medicine students Ashley Adile, Giancarlo Gillespie, Wale Adegorite and Sabahat Balaban. Copyright McMaster University 2018 References: 1. NIH's Definition of a Clinical Trial | grants.nih.gov [Internet]. [updated 2017 Aug 8; cited 2018 Mar 4]. Available from: https://grants.nih.gov/policy/clinica... 2. Canada H. Clinical Trials and Drug Safety - Canada.ca [Internet]. 2013 [updated 2013 May; cited 2018 Mar 4]. Available from: https://www.canada.ca/en/health-canad... 3. Ramers-Verhoeven C, Perrone F, Oliver K. Exploratory research into cancer patients’ attitudes to clinical trials. ecancermedicalscience [Internet]. 2014 May [cited 2018 Feb 17];2014;8:432. Available from: https://www.ncbi.nlm.nih.gov/pmc/arti... 4. DasMahapatra P, Raja P, Gilbert J, Wicks P. Clinical trials from the patient perspective: survey in an online patient community. BMC Health Services Research [Internet]. 2017 Feb [cited 2018 Feb 14];17(1):166. Available from: https://www.ncbi.nlm.nih.gov/pubmed/2... 5. Brain Tumour Foundation of Canada: Research & Clinical Trials [Internet]. 2018 [cited 2018 Mar 5]. Available from: https://www.braintumour.ca/2766/resea... 6. Canadian Brain Tumour Consortium. Canadian Brain Tumour Consortium [Internet]. 2016 [updated 2018 Mar; cited 2018 Mar 6]. Available from: http://www.cbtc.ca 7. Ontario Cancer Trials [Internet]. 2018 [updated 2018 Mar; cited 2018 Mar 6]. Available from: http://www.ontario.canadiancancertria... 8. It Starts With Me [Internet]. 2018 [cited 2018 Mar 6]. Available from: http://itstartswithme.ca 9. Canadian Cancer Trials [Internet]. [updated 2018 Mar; cited 2018 Mar 6]. Available from: http://www.canadiancancertrials.ca/ 10. Canadian Cancer Clinical Trials Network [Internet]. 2013 [cited 2018 Mar 6]. Available from: http://3ctn.ca 11. Brain Tumour Foundation of Canada: Patient Handbooks [Internet]. 2018 [cited 2018 Mar 6]. Available from: https://www.braintumour.ca/243/patien... 12. Brain Tumour Foundation of Canada: BrainWAVE Program [Internet]. 2018 [cited 2018 Mar 6]. Available from: https://www.braintumour.ca/97/brainwa... 13. Brain Tumour Foundation of Canada [Internet]. 2018 [updated 2018; cited 2018 Mar 6]. Available from: http://www.braintumourevents.ca/ 14. Brain Tumour Foundation of Canada: One-on-One Support [Internet]. 2018 [cited 2018 Mar 6]. Available from: https://www.braintumour.ca/617/one-on... Additional Resource Links: ClinicalTrials.gov is essentially the same as Ontario Cancer Trials, but for the United States. The International Brain Research Organization (IBRO) aims to promote and support neuroscience around the world, with schools situated globally to achieve their mission of advancing the work of individual scientists and research communities. Their focus is on training young scientists and striving to bridge connections between young and more established neuroscientists. National Brain Tumor Society (US) strives to provide a comprehensive list of resources and support services for the brain tumour community, with one key feature being their US clinical trial finder. The Ontario Institute for Cancer Research is a non-for-profit research institute that focuses on implementing new findings in cancer research to the clinic. They achieve this through collaboration of translational work from numerous interdisciplinary scientists across Ontario. Additional Clinical Trial Paper: Ibrahim G, Chung C, Bernstein M. Competing for patients: an ethical framework for recruiting patients with brain tumors into clinical trials. J Neurooncol [Internet]. 2011 [cited 2018 Mar 13];104:623–627. Available from: https://link.springer.com/content/pdf... This describes an ethical dilemma for patients eligible for multiple clinical trials, with the decision to: 1) let patient choose after full disclosure (i.e. discuss risks and treatment), 2) have healthcare provider choose in paternalistic approach or 3) employ random approach of either option.