St. John's Wort: Unknown Benefit For Depression (Blocks Negative Emotions/Fear). скачать в хорошем качестве

St. John's Wort: Unknown Benefit For Depression (Blocks Negative Emotions/Fear).

St. John's Wort: Unknown Benefit For Depression (Blocks Negative Emotions/Fear). ✅ FIX YOUR PERFORMANCE WITH A PERSONALIZED PLAN + GET TWO FREE E-BOOKS: https://bit.ly/LucasVIPCoaching 🔥 Want More Energy, Unstoppable Drive & Better Libido? Try My New Supplement Here: https://www.inb4supps.com/ 🌎 My Website: https://www.boostyourbiology.com/ St. John’s wort (Hypericum perforatum) is a low-growing ground cover plant that is blanketed with cheerful yellow flowers around the time of St. John the Baptist’s birthday in late June. It has a 2,000-year-old history as a natural remedy and was mentioned in works of Hippocrates and Pliny. SJW seems like it could be used for so many different conditions. It's downregulation of B1 Adrenoceptor basically makes it a long term beta blocker, something that would be pretty useful for anxiety disorders like SAD. Additionally the GABA antagonism could promote long term GABA upregulation, another factor that could assist anxiety sufferers. SJW was actually the only substance I could find that actually upregulates 5-ht1a specifically, a serotonin receptor that supposedly is the main receptor responsible for the anti-depressant effects of SSRIs(They eventually desensitize it). 5-ht1a agonism facilitates dopamine release in the prefrontal cortex. 5-ht1a agonism also produces analgesia. Antagonism of NMDA and AMPA receptors would probably promote long term upregulation of these receptors. This could underlie SJW's pro cognitive effects, utilizing a similar mechanism to the racetams(They are PAMs of AMPA, and cause subsequent NMDA upregulation). The facilitation and modulation of acetylcholine release definitely contributes to this. SJW is also a highly effective antidepressant, being as or slightly more effective than prescription SSRIs in mild-moderate depression with a side effect profile similar to placebo.(3) Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort.[13] It is a TRPC6 receptor agonist and, consequently, induces noncompetitive reuptake inhibition of monoamines including serotonin, norepinephrine, dopamine, and of GABA and glutamate, with IC50 values of 0.05-0.10 μg/mL for all compounds, with the exception of glutamate, which is in the 0.5 μg/mL range.[14] Hyperforin also inhibits the reuptake of glycine[15] and choline (IC50=8.5μM).[16] It modulates acetylcholine release in rat hippocampus and facilitates acetylcholine release in the striatum.[17][18] It antagonises the NMDA receptor, AMPA receptor and GABA receptors.[20][21] [...] Moreover, SJW is known to downregulate the β1 adrenoceptor and upregulate postsynaptic 5-HT1A and 5-HT2A receptors, both of which are a type of serotonin receptor.[5] [...]Procognitive effects of hyperforin have been observed in rats.[12] In vivo evidence suggests its efficacy against Alzheimer's disease,[20][31] an action it seems to share with its analogue, tetrahydrohyperforin.[32][33][34] [...]Hyperforin is also a powerful anti-inflammatory compound with anti-angiogenic, antibiotic, and neurotrophic properties.[45][46][50] ]Moreover, a hyperforin-free extract of St John's wort (Remotiv) may still have significant antidepressive effects.[52][53][...] Its action on TRPC6 may enable it to protect from ischaemic brain injury.[22] Its action on the TRPC6 cation channel is also believed to be responsible for its BDNF-like modulation of dendritic spine morphology in hippocampal pyramidal neurons.[23] DISCLAIMER: The information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Lucas Aoun and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program. #Stjohnswort #Hypericum