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Assuming Hypoactive Sexual Desire Disorder (HSDD) exists as a real medical disease, the recently marketed Vyleesi fails to provide significant relief. In fact independent researchers from UCLA suggest if Vyleesi offers any benefit at all, it barely differentiates itself from an inactive a placebo. Vyleesi will only be available through specialty pharmacies. It is self-injected in a manner similar to insulin just beneath the skin’s surface about 45 minutes before planned sexual activities. Unfortunately a significant number of women suffer sufficient nausea about an hour after the injection that they require anti-emetic therapy to prevent vomiting. Fortunately this effect seems to wear diminish over time. Even according to company funded studies that led to FDA approval, the difference between Vyleesi and placebo appears extremely limited. Participants in the studies were provided with Vyleesi and told not to inject themselves more than once a day and not more than about 12 times a month. Women opted to use Vyleesi on average only 2-3 times a month or about 10 times over an extended 168 day period. To make matters even worse, Vyleesi is very expensive.