Mutation, selection and evolutionary rescue in simple phenotype...(Lecture 3) by Guillaume Martin скачать в хорошем качестве

Mutation, selection and evolutionary rescue in simple phenotype...(Lecture 3) by Guillaume Martin

PROGRAM FIFTH BANGALORE SCHOOL ON POPULATION GENETICS AND EVOLUTION (ONLINE) ORGANIZERS: Deepa Agashe (NCBS, India) and Kavita Jain (JNCASR, India) DATE: 17 January 2022 to 28 January 2022 VENUE: Online No living organism escapes evolutionary change, and evolutionary biology thus connects all biological disciplines. To understand the processes driving evolution, we need a theoretical framework to predict and test evolutionary changes in populations. Population genetic theory provides this basic framework, integrating mathematical and statistical concepts with fundamental biological principles of genetic inheritance, selection, mutation, migration and random genetic drift. Population genetic models allow us to make quantitative predictions that can inform an experimentalist while designing new experiments, and give us a deeper understanding of how evolution works. This School will cover topics such as evolutionary rescue, mechanisms and dynamics of molecular evolution, microbial range expansions and the use of pedigrees in population genetics. For each topic, lectures will begin with basic concepts and end with recent advances in the field. A series of research seminars will also introduce participants to ongoing research in evolutionary biology in India. CONTACT US: [email protected] PROGRAM LINK: https://www.icts.res.in/program/popge... Table of Contents (powered by https://videoken.com) 0:00:00 Start 0:00:16 Some reviews on the subjects of these lectures 0:01:27 Genetic basis of ER: 1 step 0:02:45 Genetic basis of ER: 2 steps 0:05:21 Phenotype fitness landscapes in ER theory 0:09:51 Isotropic Fisher Model for growth rate 0:16:39 Useful results from the isotropic Fisher Model 0:23:17 Feller diffusion for demography 0:32:03 Useful results for Feller diffusion 0:35:06 Alternative strategies 0:37:57 1 step ER: SSWM 0:43:04 2 step ER: SSWM 0:53:39 Feller diffusion for demography 0:56:43 From SSWM to WSSM: ER probabilities 0:59:17 WSSM: ER probabilities 1:01:33 WSSM: distribution of extinction times 1:03:22 WSSM: mutation proof stresses 1:13:01 Luminescence monitoring of ER in E. coli 1:19:42 Isotropic Fisher Model for growth rate 1:23:16 Useful results from the isotropic Fisher Model 1:25:07 Q&A 1:25:49 Thank You