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A joint webinar from ISHLT's Advanced Heart Failure and Transplantation Interdisciplinary Network and the International Cardio-Oncology Society (IC-OS). As immune checkpoint inhibitors, CAR-T therapies, and other oncologic treatments are increasingly used across a range of malignancies, clinicians are encountering growing challenges in managing cancer in patients with heart transplants. Similarly, as the population ages and survival improves with durable LVAD support, the question of how best to approach cancer care in these patients is becoming more common. This joint session between ISHLT and IC-OS will feature real-world case presentations to highlight key considerations in the care of transplant and MCS recipients undergoing cancer therapy. Expert discussants will explore issues surrounding immunosuppression management, rejection risk, bleeding and thrombosis in the setting of chemotherapy, and strategies for multidisciplinary coordination. Attendees will come away with clinically actionable insights for navigating these complex scenarios. Moderator: Richard Cheng, MD, MSc Presentations: Case-Based Presentations: Checkpoint at the Crossroads: Immunotherapy After Heart Transplant Presented by Yael Peled, MD Collateral Risk: Managing Malignancy in Patients with Durable LVADs Presented by Farookh Sheikh, MD Panel Discussion With panelists Bhavadharini Ramu, MD and Margot Davis, MD