Colter Mitchell, Research Associate Professor, University of Michigan, CAPS Speaker February 20, 206 скачать в хорошем качестве

Colter Mitchell, Research Associate Professor, University of Michigan, CAPS Speaker February 20, 206

CAPS Lecture Series: Colter Mitchell, Research Associate Professor, University of Michigan "Seeds of Disease (and Residue of Exposures): Using Biomarkers to Trace Health Across the Life Course." Abstract: As the United States rapidly transitions into an aging society, the prevalence and cost of aging-associated diseases are soaring. Alarmingly, recent cohorts entering adulthood and midlife are less healthy compared to previous generations at the same ages, suggesting a faster rate of aging and underscoring the urgent need for earlier detection of age-related diseases—often well before midlife. Adding complexity, early-life social adversities have profound and lasting impacts on aging and related diseases, yet they are notoriously difficult to measure accurately in older populations. To address these gaps, we leverage survey and biorepository data from three large, nationally representative panel studies: the Health and Retirement Study (HRS; representing Americans over age 50, with biomarker data for ages 51-110), the National Longitudinal Study of Adolescent to Adult Health (Add Health; following adolescents in grades 7-12 since 1994, with biomarker data for ages 24-42), and the Future of Families and Child Wellbeing Study (FFCW; tracking births in large U.S. cities from 1998-2000, with biomarker data for ages 9-24). Using an array of blood-based biomarkers—including IL-6, TNFα, CRP, GDF15, IGF-1, cystatin C, NT-proBNP, and HbA1c—as well as measures of inflammation and DNA methylation, we reveal that signatures of disease emerge early in life. Critically, some biomarkers linked to early-life exposures serve as predictors of health outcomes well into later life. Our findings illuminate the biological footprints of adversity and disease across the lifespan and highlight potential actionable pathways for early intervention.