MRCEM PART 1|Physiology Part 3 скачать в хорошем качестве

MRCEM PART 1|Physiology Part 3

Renal Physiology Part 3: Calcium, Diuretics, & GFR Basics Welcome to Physiology Part 3 of our MRCEM revision series! Today, we finalize our look at electrolyte handling and start discussing glomerular function, covering high-yield topics essential for your exam. 1. Calcium Reabsorption Freely Filtered: Calcium passes easily into the nephron. Regulated in DCT: Fine-tuning occurs in the Distal Convoluted Tubule (DCT). Hormonal Control: Parathormone (PTH) and Activated Vitamin D (D3) control the Calcium ATPase channel on the basolateral membrane (into the blood). The Sodium-Calcium Antiporter works independently. 2. Diuretics: Mechanism and Side Effects Osmotic Diuretics (e.g., Mannitol): Not reabsorbed, stay in the tubule, draw water out, causing polyuria (e.g., in uncontrolled diabetes). Loop Diuretics (Most Potent): Inhibit the Sodium-Potassium-2-Chloride Symporter in the Loop of Henle. Major side effect: Hypokalemia. Thiazide Diuretics: Inhibit the Sodium-Chloride Co-transporter in the early DCT. Indirectly cause Hypokalemia via aldosterone activation. Potassium-Sparing Diuretics (e.g., Spironolactone, Amiloride): Aldosterone inhibitors that prevent Potassium excretion, counteracting hypokalemia. 3. Glomerular Filtration Rate (GFR) Filtration Fraction: The percentage of plasma filtered by the kidney. FF=GFR/RPF=120/600=20%. Protein Concentration: Proteins are not filtered, becoming more concentrated in the Efferent Arteriole. Starling Forces: Filtration is driven by Hydrostatic Pressure (35 mmHg) and opposed by Oncotic Pressure (25 mmHg). Net Filtration Pressure (NFP): 10 mmHg (Hydrostatic is greater, so filtration occurs). Join us in the next video as we complete the discussion on the Filtration Barrier! Hit like and subscribe! #emergencymedicine #DNBResidency #DNBResident #mrcempreparation #EmergencyMedicineIndia #medicaleducation #residentlife #doctorsofindia #medicolife #medicalcommunity #DNBEmergencyMedicine #MRCEMGuidance #DNBJourney #EmergencyMedicineResident #residencytips #clinicalskills #emergencycare #LifeInER #erdoctor #doctorvlogs #medstudent #futuredoctor #healthcareindia #MedicineCareer #medicalmotivation