What is Portal Hypertension in Liver Cancer and Bile Duct Cancer? скачать в хорошем качестве

What is Portal Hypertension in Liver Cancer and Bile Duct Cancer?

Learn more about BILE DUCT CANCER at https://www.BileDuctCancerExpert.com Blockage or Occlusion of the venous blood supply to the liver can lead to other complicating issues that can make dealing with bile duct cancer or cholangiocarcinoma and other liver cancers or GI cancers more complicated. The occlusion of a portal vein or hepatic veins can often be from a bland thrombus also known as a blood clot. Cancer can increase your risk of developing these types of blood clots. Sometimes cancer causes a tumor thrombus, which means there is invasion of the tumor into the blood vessel itself. When there is a Blockage of a Portal Vein and especially a MAIN portal vein, this situation can lead to increasing pressure in the liver blood supply or in the portal venous Circulation. This situation leads to what is known as Portal Hypertension which is elevated blood pressures in the liver blood supply and is a very serious condition that complicates the cancer treatment. When there is portal hypertension often that can lead to liver dysfunction or the liver not working properly. When the liver is not working properly, this can lead to other types of comorbid conditions or other disease problems. This also makes treatment of cancers like Bile duct cancer or cholangiocarcinoma, more Difficult. A patient will likely see changes in their liver function tests. They might see the development of Ascites which is fluid that can build up in the abdomen and the peritoneum. A patient may also see development of things like varices which are dilated veins that can run along the esophagus and and stomach and can cause a risk for internal bleeding. So the development of portal hypertension is usually a slow process but often times one of the initiating acute factors could be occlusion of things like the portal vein due to a tumor thrombus. Reference: Portal hypertension (PHT) and Liver Cancer (including hepatocellular carcinoma and cholangiocarcinoma) are 2 major complications of liver disease and cirrhosis that often coexist in the same patient and impact the prognosis, especially in patients with acute variceal bleeding. Allaire, Manon, and Dominique Thabut. “Portal hypertension and variceal bleeding in patients with liver cancer: Evidence gaps for prevention and management.” Hepatology (Baltimore, Md.) vol. 79,1 (2024): 213-223. doi:10.1097/HEP.0000000000000291 Learn more at https://www.BileDuctCancerExpert.com About the Faculty: Dr. Rachna T. Shroff, MD, MS, FASCO Interim Chief of Hematology and Oncology Professor of Medicine, Tenure Chief, Section of GI Medical Oncology Leader, University of Arizona Cancer Center GI Clinical Research Associate Director, Clinical Investigations for University of Arizona Cancer Center Associate Dean, Clinical and Translational Research – UA College of Medicine-Tucson Associate Professor, Cancer Biology-GIDP Medical Director, Arizona Clinical Trials Network (ACTN) Department of Medicine, Division of Hematology/Oncology