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Khalid Shah, professor at Harvard Medical School and director of the Stem Cell Therapeutics and Imaging Program at Massachusetts General Hospital, reviewed the lack of progress in treatment for glioblastoma multiforme over the last 25 years – a period which has seen only a 2-month increase in average survival, despite many promising pre-clinical publications. Having identified poor animal models as a major reason for this translational failure, Dr. Shah led the development of a clinically realistic mouse model for primary GBM treatment by resection. His group’s subsequent invention of a stem cell-enriched hydrogel that can be inserted into the resection cavity to eliminate residual tumor cells is now progressing rapidly towards clinical trials. This video was recorded at Rejuvenation Biotechnology 2016, a SENS Research Foundation conference held at the Buck Institute for Research on Aging on August 16-17, 2016. For more information, visit http://www.sens.org/rb2016