Tip-138; Pilocytic astrocytoma presenting with leptomeningeal metastasis скачать в хорошем качестве

Tip-138; Pilocytic astrocytoma presenting with leptomeningeal metastasis

Tip-138; Pilocytic astrocytoma is a grade-1 tumor, composed of a proliferation of bipolar hair-like pilocytic cells, thus the name, arranged in variable compact and loose or myxoid regions, with Rosenthal fibers, and eosinophilic granular bodies seen in between. It is associated with MAPK pathway gene alterations, most often KIAA1549::BRAF gene fusions. In the posterior fossa, PA appears as a cystic lesion with a solid mural nodule amenable to gross total resection.  Pilocytic astrocytoma accounts for 17.6% of all childhood primary brain tumors and is the most common glioma in children. The incidence rate is highest in young children and decreases with advancing age. Primary dissemination may be seen at diagnosis and is more common in infants. However, neuraxis seeding does not necessarily indicate aggressive growth. Seeding may be asymptomatic, and long-term survival is possible, even without adjuvant treatment.