High-resolution spatial mapping of Alzheimer’s Disease with COMET™ скачать в хорошем качестве

High-resolution spatial mapping of Alzheimer’s Disease with COMET™

In this video presentation, Dr. Josué Ballesteros Alvarez, Application Development Scientist at Lunaphore, is highlighting how the flagship COMET™ platform revolutionizes Alzheimer's disease (AD) research. Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-β plaques, neurofibrillary tangles, neuronal loss, and cognitive impairment. While our understanding of AD has evolved, mapping the cellular and molecular interplay between neurodegeneration and neuroimmunology remains challenging. The novel data were presented at the Immunology 2025 Annual Meeting, offering new insights into the spatial relationships between neurodegenerative lesions and neighboring cells, shedding light on the neuroimmune landscape of AD. About Lunaphore Lunaphore Technologies S.A. – a Bio-Techne brand, is a Swiss company born in 2014 with the vision of enabling spatial biology in every laboratory. Lunaphore provides solutions based on a game-changing chip technology that can extract spatial proteomic and transcriptomic data from tumors and other tissues, transforming any assay into multiplex spatial biology through a streamlined and easily integrated process. Lunaphore empowers researchers in immunology, immuno-oncology, and neuroscience to push the boundaries of scientific discovery and drug development. Lunaphore’s technology enables the identification of biomarker “signatures” with clinical relevance to support the development of diagnostic tools and streamline clinical trials, to ultimately improve patient outcomes. For further information on Lunaphore and its products, please visit https://lunaphore.com. About COMET™ COMET™ is the only fully automated, high-throughput, hyperplex platform ensuring scalability and reproducibility without the need to conjugate primary antibodies. COMET™ provides walk-away automation, integrating staining, imaging, and image preprocessing steps to obtain standard hyperplex images. The multiomics capability of COMET™ enables the simultaneous analysis of both RNA and protein data within the spatial context of tissues to enhance the understanding of cellular dynamics and disease processes. COMET™ generates highly robust and reproducible data with full tissue preservation, allowing researchers to perform downstream modalities such as H&E or transcriptomics using the same slide. Its superior tissue profiling capabilities facilitate the analysis of 40 different spatial markers in each automated run on a tissue slide. In contrast to other spatial biology solutions, COMET™ works with off-the-shelf, label-free primary antibodies, making panel design much more flexible and faster than any other hyperplex solution. COMET™ works with regular glass slides from standard histology workflows; it is validated for human and mouse samples and is compatible with any other animal sample. The platform can be used for a wide range of research applications, allowing for a dramatic improvement in the understanding of disease pathology. To learn more about the COMET™ platform, please visit: https://lunaphore.com/products/comet/ Connect with Lunaphore online: Website: https://lunaphore.com/ LinkedIn:   / lunaphore   Twitter:   / lunaphore   Instagram:   / lunaphore   ©2025 Lunaphore Technologies SA