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vol.4/4) LH-RH Agonists? NOT Antagonists?: Mechanism of Action Simplified.

(side note) LH-RH agonists: ‣Goserelin (ZOLADEX®) ‣Leuprolide (Eligard®, Lupron Depot®) The video explains breast cancer hormone therapy, covering receptor blockade, estrogen synthesis inhibition, and estrogen secretion suppression using SERMs, aromatase inhibitors, and LH-RH agonists. It's a concise guide for understanding breast cancer treatment methods. #cancertreatment #breastcancer #hormonetherapy 【Study Break Oasis】 5-Min Forest Oasis: Healing Sounds for Study Stress    • 5-Min Forest Oasis: Healing Sounds for Stu...   5-Min Seaside Serenity: Waves of Calmness for Study Stress    • 5-Min Seaside Serenity: Waves of Calmness ...   【Learn about Hormone Therapy for Breast Cancer】 vol 1/4) Why is Hormone Therapy used for Breast cancer?    • vol.1/4) What is Hormone Therapy for Breas...   vol 2/4) SERMs: Tamoxifen (Nolvadex®, Soltamox®), Raloxifene (Evista®)    • vol.2/4) What is SERMs?   vol 3/4) Aromatase inhibitors: Anastrozole (Arimidex®), Letrozole (Femara®), Exemestane (Aromasin®),    • vol.3/4) Do you know the mechanism of acti...   vol 4/4) LH-RH agonist: Goserelin (ZOLADEX®), Leuprolide (Eligard®, Lupron Depot®)    • vol.4/4) LH-RH Agonists? NOT Antagonists?:...   【Learn about Hormone Therapy For Prostate Cancer】 vol 1/3) Why is Hormone Therapy used for Prostate Cancer?    • vol.1/3) Hormone Therapy for Prostate Canc...   vol 2/3) Androgen Receptor and Androgen Synthesis Abiraterone (ZYTIGA®, Yonsa®), Ketoconazol (Nizoral®), Flutamide (Eulexin®), Bicalutamide (Casodex®)., Mechanism    • vol.2/3) CYP 17 inhibitors?: Abiraterone, ...   vol 3/3) LH-RH agonist or antagnist? Goserelin (ZOLADEX®), Leuprolide (Eligard®, Lupron Depot®), Degarelix (Firmagon®), Mechanism    • vol.3/3) LH-RH Agonist or Antagonist?   【Notes】 ▹This video was created based on data as of April 2024, with the purpose of supporting medical students in their exam preparations. ▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited. 【Reference and figure】 I express my gratitude and respect for your wonderful achievements. 1. Weatherman, R. Untangling the estrogen receptor web. Nat Chem Biol 2, 175–176 (2006). https://doi.org/10.1038/nchembio0406-175 2. Cui J, Shen Y, Li R. Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol Med. 2013 Mar;19(3):197-209. doi: 10.1016/j.molmed.2012.12.007. Epub 2013 Jan 22. PMID: 23348042; PMCID: PMC3595330. 3. NIH national cancer institute, NCI dictionary of Cancer terms, selective estrogen receptor modulator. https://www.cancer.gov/publications/d... 4. Riggs BL, Hartmann LC. Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice. N Engl J Med. 2003 Feb 13;348(7):618-29. doi: 10.1056/NEJMra022219. Erratum in: N Engl J Med. 2003 Mar 20;348(12):1192. PMID: 12584371. 5. Farrar MC, Jacobs TF. Tamoxifen. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NB... 6. Quintanilla Rodriguez BS, Correa R. Raloxifene. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NB... 7. Nedresky D, Singh G. Physiology, Luteinizing Hormone. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NB... 8. Chan HJ, Petrossian K, Chen S. Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells. J Steroid Biochem Mol Biol. 2016 Jul;161:73-83. doi: 10.1016/j.jsbmb.2015.07.018. Epub 2015 Aug 13. PMID: 26277097; PMCID: PMC4752924. 9. NIH national cancer institute, NCI Dictionary of Cancer Terms, “ LH-RH”. https://www.cancer.gov/publications/d... 10. Schally AV, Comaru-Schally AM. Mode of Action of LHRH Analogs. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available from: https://www.ncbi.nlm.nih.gov/books/NB...