Unlocking the Secrets: Adult Neurogenesis in Alzheimer's and Cognitive Resilience скачать в хорошем качестве

Unlocking the Secrets: Adult Neurogenesis in Alzheimer's and Cognitive Resilience

Ahmed Disouky, *et al.*, in *Nature*, 2026, reveals a groundbreaking study on human hippocampal neurogenesis. This video breaks down their research exploring how new neurons are generated in the adult human brain, specifically in the hippocampus. The study investigates this process across different groups: young adults with good memory, healthy older adults, "SuperAgers" with exceptional memory, those with early signs of Alzheimer's, and those with Alzheimer's. Using advanced single-cell sequencing techniques, the researchers identified key differences in neurogenesis among these groups. They discovered changes in how DNA is accessed and read in cells involved in neurogenesis, especially in those with preclinical Alzheimer's. Interestingly, "SuperAgers" showed a unique pattern of neurogenesis potentially linked to their memory resilience. The research also highlighted the role of astrocytes (star-shaped brain cells) and specific neurons in regulating brain function as we age. This research doesn't offer a cure, but it provides valuable insight into the molecular signature of the aging hippocampus which potentially can offer therapeutic strategies in the future. *Full Citation:* Disouky, A., Sanborn, M.A., Sabitha, K.R. et al. Human hippocampal neurogenesis in adulthood, ageing and Alzheimer's disease. Nature (2026). https://doi.org/10.1038/s41586-026-10...