580-Planetary Microbiome and Generalist-Driven Gene Flow скачать в хорошем качестве

580-Planetary Microbiome and Generalist-Driven Gene Flow

This research presents a global framework for understanding the planetary microbiome by analyzing over 85,000 metagenomes to map how microbes are structured across diverse habitats. By integrating taxonomic and functional data, the study identifies generalist species that possess the unique metabolic versatility required to thrive in multiple, ecologically distinct environments. These generalists act as critical bridges, facilitating horizontal gene flow between disparate settings, such as the transfer of genes from human guts to wastewater and eventually into the broader environment. A key finding highlights how this connectivity drives the global dissemination of antimicrobial resistance (AMR) through specific genomic islands shared between generalists and specialists. The authors demonstrate that while environmental selection remains a primary driver of microbial community structure, human activities increasingly amplify the spread of clinical threats via these ecological mediators. Ultimately, this work provides a standardized model for monitoring global gene flow and predicting how anthropogenic pressures reshape the earth's microbial landscape. References: • Kim C Y, Podlesny D, Schiller J, et al. Planetary microbiome structure and generalist-driven gene flow across disparate habitats[J]. bioRxiv, 2025: 2025.07. 18.664989.