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The HER2 gene, short for Human Epidermal growth factor Receptor 2 gene, provides the recipe for making the HER2 protien, a receptor that sits within the surface of certain cells. When these receptors pair up, they generate a signal that can tell a cell to divide. In healthy cells, these signals are regulated. There are two copies of the HER2 gene, and they produce just the right number of HER2 receptors that the cell needs to function normally. In cancer cells, however, the cells sometimes have extra copies of the HER2 gene, known as HER2 gene amplification. These extra genes can direct the cell to make way too many HER2 receptors, called HER2 overexpression. Tumor cells with HER2 gene amplification, or HER2 receptor overexpression, are called HER2+ cells. This is a clip from a Lumination we produced for CancerCare, called HER2 in Gastric Cancer. For the full video, visit: • HER2 in Gastric Cancer To learn more about HER2 and other biomarkers from CancerCare, visit: https://www.cancercare.org/biomarkers. For more Luminations, LIKE this video and SUBSCRIBE: https://www.youtube.com/@Luminations-... Interested in producing a Lumination? Visit whttps://www.luminations.health/ #Luminations #HER2positive #Cancer #CancerCare #Biomarkers #PatientEducation #PatientEd You and your doctor are a team in your care. This video is for informational purposes only and is not intended to be a substitute for medical advice. Talk with your doctor to decide the right course of treatment for you. About Luminations: Luminations offer an innovative take on patient education videos. Each short educational video is packed with visual metaphors that introduce your audience to new scientific concepts using familiar references. Hand-drawn animation makes our diverse cast of characters more emotive and expressive—and thus more relatable—than traditional explainer patient education videos online. And our lighthearted approach makes it easier for patients to be more open to learning about their disease and treatment options.