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R Walker, H Waterson, P Koopmans, R Stroud, J Phillips, V Mandalia, K Eyres, A Toms Ligament balancing versus Measured Resection: A Randomised Controlled Trial To Evaluate The Effect Of Different Alignment Philosophies In Total Knee Replacement On Functional And Patient-Reported Outcomes Robert Walker Authors Hugh Waterson1, Robert Walker1, Petra Koopmans2, Rowenna Stroud1, Jonathan Phillips1, Vipul Mandalia1, Keith Eyres1, Andrew Toms1 Institution Royal Devon and Exeter Hospital Abstract Background This randomised trial compared functional and patient-reported outcomes (PROMs) of the Unity Knee™ (Corin Ltd) using two philosophies for alignment: Measured Resection (MR) and an individualised alignment philosophy using a Gap Balancer (GB). Method 94 knees were randomised. Primary outcome was quadriceps strength; secondary outcomes included KOOS, OKS, EQ-5D and validated functional tests. Outcomes were assessed pre-operatively, at 6 weeks, 3, 6 and 12 months post-operatively. Results At 12-months 90 knees were assessed. Change in quadriceps peak torque showed no significant difference in between the two groups (p=0.988). At 3 months there was a significant improvement in the change in range of motion in the GB group compared to the MR group (13° vs 6° p=0.028). The functional tests of Wii Fit Balance and Timed Up and Go (TUG) showed statistically significant improvement at 6 weeks and 3 months respectively (p=0.03) in the GB group compared to the MR group. PROMs favoured the LB group with the KOOS pain scoring statistically better (p≤0.05) at 6 weeks, 3, 6 and 12 months. Conclusion Compared to a MR technique, the GB technique appears to confer improvement in several functional and patient-reported outcomes following TKR in the short-term.