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Watch the Full Video at https://www.jove.com/v/4079/stereotax.... Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat - a 2 minute Preview of the Experimental Protocol Elizabeth D. Kirby, Kelly Jensen, Ki A. Goosens, Daniela Kaufer University of California Berkeley, Helen Wills Neuroscience Institute; University of California Berkeley, Office of Laboratory Animal Care; Massachusetts Institute of Technology, McGovern Institute for Brain Research & The Department of Brain and Cognitive Science; University of California Berkeley, Integrative Biology Department; Targeted ablation of specific brain region(s) by infusion of an excitotoxin using stereotaxic coordinates is described. This technique could also be adapted for infusion of other chemicals into the rat brain. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments