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What Is Oncotype DX

Oncotype DX is a multi-gene RT-PCR-based, quantitative gene expression assay for breast cancer performed by Genomic Health clinical laboratory in Redwood City, CA. The test involves analyzing the expression levels of 21 genes - 16 cancer-related genes and 5 reference genes - in the RNA extracted from breast tumors samples and calculating a Recurrence Score (RS) on a scale from 0 to 100 from the reference normalized expression measurements. In clinical study results recently reported at the San Antonio Breast Cancer Symposium in February of 2022, patients with hormone receptor-positive (HR+) breast cancer and 1-3 positive lymph nodes and a recurrence score of less than 25 benefited from the addition of chemotherapy to endocrine therapy in terms of improved disease-free survival if they were premenopausal. Post-menopausal women, however, did not have disease-free survival benefit with chemotherapy, which means that these women may be spared the chemotherapy. In plain language, Oncotype DX (Dx is the medical abbreviation for diagnosis) is a laboratory test that is used to help predict whether breast cancer will spread to other parts of the body or recur, which means that the cancer will return. The recurrence score may be able to help the oncologists determine which patients may need to be treated with chemotherapy drugs because there is a higher risk that their cancer will spread or recur and which patients may be spared toxic chemotherapy because they are not likely to benefit from it. Here is the list of 21 genes included in the Oncotype DX assay: BAG1, B-actin, Bcl2, CCNB1, CD68, CTSL2, Esrt1, GAPDH, GRB7, GSTM1 GUS, HER2, Ki-67, MYBL2, PR, RPLPO, SCUBE2, STK15, STMY3, SURV, TFRC How to pronounce Oncotype DX in American English or U.S. English. How to pronounce Oncotype DX. What Is Oncotype DX. What does Oncotype DX mean? Definition of Oncotype DX. What does Oncotype DX stand for?