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Synthetic cannabinoids are a class of chemicals that bind to cannabinoid receptors in the body, but that are different from the natural cannabinoids in cannabis . J.T. Nicholson presents. Synthetic cannabinoids are a class of chemicals that bind to cannabinoid receptors in the body, but that are different from the natural cannabinoids in cannabis plants. They are often marketed. Under the subheading of “herbal incense”, Spice and K2 are made from plant material that is laced with synthetic cannabinoids, which are chemically similar to . Synthetic cannabinoids. Legal highs are set to be outlawed by the British government in response to a growing number of news reports about students overdosing on the synthetic drugs after using them re