Transparency and clinical guidelines by Holger Schunemann скачать в хорошем качестве

Transparency and clinical guidelines by Holger Schunemann

Introduction: Content: The solution-guidelines: a: Clinical Practice Guidelines b: A COPD guideline c: Another COPD guideline Wich approach? What to do? Hierarchy of evidence based on quality Explain the following? a: Evidence: parachute randomised controlled risks Simple hierarchies are (too) simlistic: a: A systematic review of randomized trials in cancer patients b: Do you have confidence in these estimates of effects? c: High confidence in the effects d: a systematic review of the literature on the treatment of pityriasis ruba pilaris e: How confident are you in the estimates of effect? GRADE quality of Evidence: a: GRADE Working Group b: GRADE Uptake Elephant in the room: a: Confidence based healthcare decisions b: Determinants of confidence c: Quality assessme,t criteria GRADE: quality of (a body of) evidence & recommendations: a: Evidence based healthcare decisions b: Strength of recommendation c: Determinants of the strength of recommendation Balancing desirable and undesirable consequences High confidence in the effects Implications of a conditional/weakRecommendation Implications of a strong recommendation Systematic review and guideline development Conclusions