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This Harvard Medical School Continuing Education video examines these key questions: How should you follow up on patients with aortic stenosis (AS)? What medical therapies are best for patients with AS? When are aortic valve replacements indicated? Dr. Evin Yucel, MD, FACC, a cardiologist at Massachusetts General Hospital, reviews the 2020 ACC/AHA Guidelines for the Management of Patients with Valvular Heart Disease, focusing on patient follow-up by risk stage. Medical therapies for treating aortic stenosis, including indications for aortic valve replacement and bicuspid valve replacement, are identified. Symptomatic and asymptomatic patients are discussed. 00:00 | Introduction 00:37 | 2020 ACC/AHA Guidelines for management of patients with AS 01:20 | Medical therapy for aortic stenosis: aortic valve replacement 04:12 | Medical therapy for aortic stenosis: bicuspid valve replacement This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. References: Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021;143(5):e72-e227. Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359(13):1343-1356. doi:10.1056/NEJMoa0804602. Herrmann HC, Pibarot P, Hueter I, et al. Predictors of mortality and therapy outcomes in low-flow severe aortic stenosis: a Placement of Aortic Transcatheter Valves (PARTNER) trial analysis. Circulation. 2013;127(23):2316-2326. doi:10.1161/CIRCULATIONAHA.112.001290. Notice: At this time, the content in this video is not accredited.