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Aldo de Pape speaks with Patrick Joyce and Dr. Jeffrey Koury about the challenges and opportunities in the field of decentralized science. They discuss the need for a new economic model in science due to the replication crisis, personal frustrations in academia, and the impact of financial pressures on research integrity. The discussion also covers the role of the ResearchHub and its foundation in incentivizing quality research, the importance of decentralization in scientific publishing, and the evolving landscape of funding and peer review. They reflect on their journey, the community they are building, and the importance of aligning business models with scientific values. Relevant links https://www.researchhub.com/ https://www.researchhub.foundation/ Sound bites "50 to 85% of experiments are irreproducible." "We need to fix the incentives in science." "The economy of science is extremely competitive." Chapters 00:00 Introduction to Decentralized Science 01:31 The Need for a New Economic Model in Science 04:07 Personal Frustrations in Academia 10:17 The Impact of Financial Pressure on Research 12:11 The Journey of Research Hub 17:56 Decentralization in Scientific Publishing 22:18 Peer Review and Funding in a Decentralized World 26:48 The Role of the Research Hub Foundation 30:19 Incentives and Goodheart's Law 34:38 Evaluating Other Decentralized Science Solutions 39:49 Building a Business Model that Serves Science 45:37 Reflections on the Journey 51:11 Recommended Readings and Inspirations Keywords Decentralized Science, Research Hub, Economic Model, Peer Review, Funding, Open Science, Scientific Publishing, Innovation, Academic Frustration, Science Communities