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🩺 Zollinger–Ellison Syndrome: Pathogenesis, Diagnosis & Treatment Explained (USMLE High-Yield Beginner’s Guide) Ever wondered how a rare neuroendocrine tumor leads to severe peptic ulcer disease? In this video, we break down Zollinger–Ellison Syndrome (ZES)—from its pathogenesis (gastrin-secreting tumors and gastric acid hypersecretion) to its diagnosis (elevated serum gastrin, secretin stimulation test, imaging) and treatment options (proton pump inhibitors, surgery, and management of complications). This guide is perfect for medical students, USMLE prep, and healthcare professionals looking for a high-yield review! What You’ll Learn in This Video: ✔️ Pathogenesis: How gastrin-secreting tumors (gastrinomas) lead to excessive acid production The role of the duodenum and pancreas in ZES ✔️ Diagnosis: Key laboratory findings: Elevated fasting serum gastrin levels The secretin stimulation test and imaging modalities (CT, MRI, and endoscopic ultrasound) ✔️ Treatment Options: Medical management with proton pump inhibitors (PPIs) Surgical resection strategies and managing metastases ✔️ USMLE High-Yield Pearls & Mnemonics: Quick review tips and exam mnemonics for remembering diagnostic criteria and treatment approaches ⏰ Timestamps for Easy Navigation: 0:00 How gastrinoma cause hyperproduction of HCL 3:14 Pathogenesis of clinical symptoms 6:11 Diagnostic criteria 7:36 Treatment 💬 Question for You: Have you encountered Zollinger–Ellison Syndrome in clinical practice or exams? What was the most challenging part of the diagnosis? Let us know in the comments! 😊 👍 Help Us Grow: Like this video if you found it helpful! Subscribe for more high-yield medical and USMLE content! Share this video with colleagues and classmates! ⚠️ Disclaimer: This video is for educational purposes only and should not replace professional medical advice. Always consult a healthcare provider for diagnosis and treatment recommendations. https://t.me/foxterRier_med