#56 - Muscle plasticity, aging and exercise with Dr Benjamin Miller скачать в хорошем качестве

#56 - Muscle plasticity, aging and exercise with Dr Benjamin Miller

Dr Glenn McConell chats with Professor Benjamin Miller from the Oklahoma Medical Research Foundation (OMRF) who is an expert on muscle proteostasis /plasticity in response to exercise and aging. He has evidence that muscle atrophy with aging may be due more to increased protein breakdown than reduced protein synthesis. He also has found that the top diabetes drug metformin can impair some of the benefits of exercise. 0:00. Introduction and Benjamin’s current employment etc 6:09. Benjamin’s early background in exercise and science 8:05. Healthspan vs lifespan. Can extend lifespan? 13:12. Metformin can impair some of the benefits of exercise 20:15. Metformin and healthspan/lifespan 23:05. Prescribing metformin to diabetics before diet/exercise 25:20. Drugs aren’t as good as exercise for healthspan 27:20. Proteostasis (protein homeostasis) 29:20. Muscle atrophy with aging: mainly due to protein breakdown? 36:40. Muscle fibers have many nuclei 39:00. Muscle nucleus DNA duplication 42:30. Satellite cells not so important for myonuclei? 45:45. Benjamin’s tracer study methods using D2O 49:50. Myonuclear domain, weight training, muscle memory 52:02. Mechanisms of acute atrophy vs aging 54:25. Mitochondria interactions with proteostasis 57:30. Aging drugs and interactions with exercise 59:40. Statins, exercise and muscle 1:00:20. Exercise better than drugs for healthspan 1:00:40. Lactate infusions during exercise 1:04:20. Lactate, exercise and cognitive function. 1:05:20. Tendon collagen synthesis and turnover (and exercise) 1:13:15. Muscle nuclei can migrate to damaged area 1:13:57. Takeaway messages 1:16:58. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.100.... Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell   / glenn-mcconell-83475460   ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: shorturl.at/tyGHL Apple Podcasts: shorturl.at/oFQRU YouTube:    / @insideexercise   Anchor: https://anchor.fm/insideexercise Google Podcasts: shorturl.at/bfhHI Anchor: https://anchor.fm/insideexercise Podcast Addict: https://podcastaddict.com/podcast/402... Not medical advice