乳腺癌靶向药物有哪些 景娜 山西省肿瘤医院 скачать в хорошем качестве

乳腺癌靶向药物有哪些 景娜 山西省肿瘤医院

乳腺癌靶向药物有哪些 景娜 山西省肿瘤医院 HER-2基因全称是人类表皮生长因子受体2，是一种原癌基因，每个人体内正常细胞膜表面都有少量的HER-2蛋白。HER-2蛋白可进行信号传导，调控细胞生长和分裂。当癌细胞内HER-2基因高度表达时候，细胞膜上会产生过多HER-2蛋白，刺激癌细胞增长而增加癌细胞的侵袭性。HER-2阳性的乳腺癌患者病情较为凶险，较容易出现复发转移，生存期相对较短。一般有20%到30%的乳腺癌患者都属于HER-2阳性乳腺癌。尽管HER-2阳性乳腺癌病情较风险，但目前已有抗HER-2靶向治疗，可显著改善延长患者的无进展生存。目前靶向药物商品名叫赫赛汀，也就是注射用曲妥珠单抗，适用于乳腺癌辅助新辅助以晚期乳腺癌任何阶段。另外，帕妥珠单抗与国家自主研发的比落替尼联合对晚期的转移性的乳腺癌有非常好的疗效。 What are the targeted drugs for breast cancer The full name of HER-2 gene is human epidermal growth factor receptor 2, It's a proto oncogene, There is a small amount of HER-2 protein on the surface of normal cell membrane in each human body. HER-2 protein can conduct signal transduction, Regulate cell growth and division. When HER-2 gene is highly expressed in cancer cells, Too much HER-2 protein is produced on the cell membrane, It can stimulate the growth of cancer cells and increase the invasiveness of cancer cells. Breast cancer patients with HER-2 positive were more dangerous, It is easy to have recurrence and metastasis, The survival time was relatively short. Generally, 20% to 30% of breast cancer patients belong to HER-2 positive breast cancer. Although HER-2 positive breast cancer is more at risk, However, at present, anti HER-2 targeted therapy has been used, It can significantly improve and prolong the progression free survival of patients. At present, the target drug commodity is Herceptin, That is, trastuzumab for injection, It can be used in any stage of advanced breast cancer. In addition, The combination of patozumab and bilotinib, which is independently developed by the state, has a very good effect on advanced metastatic breast cancer.