PI3K/AKT/mTOR Pathway | Cancer Biology | Basic Science Series скачать в хорошем качестве

PI3K/AKT/mTOR Pathway | Cancer Biology | Basic Science Series

PI3K/AKT/mTOR Pathway | Cancer Biology | Basic Science Series Discount code for consensus: BASICSCIENCE30 Consensus: https://consensus.app/search/ Premium subscription: https://consensus.app/subscription/ Keywords: PI3K, AKT, mTOR, cancer biology, cell signaling, proliferation, survival, metabolism, therapeutic target, PIP3, PIP2, RTKs, phosphorylation, protein synthesis, feedback regulation, PTEN, TSC1/TSC2, Rheb, S6K1, 4E-BP1, mTORC1, mTORC2, precision medicine, molecular pathway, growth factors, cellular processes. 🧬 Key Concepts in the PI3K/AKT/mTOR Pathway 1. PI3K Activation and Signal Propagation Discover how ligand binding to receptor tyrosine kinases (RTKs) initiates the cascade, leading to the generation of PIP3, a pivotal second messenger that drives downstream signaling. 2. AKT Recruitment and Activation Learn how AKT is phosphorylated and activated by PDK1 and mTORC2, enabling it to regulate processes like cell survival and metabolism. 3. mTORC1: The Master Regulator Explore how mTORC1 integrates signals from growth factors, nutrients, and energy status to control protein synthesis and cell growth through its effectors, S6K1 and 4E-BP1. 4. Regulation and Feedback Mechanisms Understand the role of key regulators like PTEN and feedback loops in maintaining the pathway’s balance and preventing hyperactivation. 🌟 PI3K/AKT/mTOR Pathway in Disease and Therapy 1. Pathway Dysregulation in Diseases o Cancer: Hyperactivation of this pathway drives tumor growth, survival, and resistance to therapies. o Metabolic Disorders: Aberrant signaling contributes to insulin resistance and obesity. o Neurodegenerative Diseases: Dysregulation impacts neuronal survival and function. 2. Therapeutic Innovations Learn how inhibitors targeting PI3K, AKT, and mTOR are revolutionizing treatments for cancer and other diseases, highlighting the pathway’s potential in precision medicine. 🔔 Don’t forget to like, share, and subscribe for more insightful videos on cell signaling and beyond! WhatsApp group: https://chat.whatsapp.com/HTXQC1Ax2qf... Twitter:   / basic_series   Facebook Group:   / 742235929758671   LinkedIn:   / basicscienceseriesa54439208   Instagram:   / basic_science_series   Support my work at https://www.patreon.com/user?u=37177596 Disclaimer: The information provided is for educational purposes only. The content of this channel should not be considered as medical advice of any kind. Use this information at your own risk. We hold no responsibility for any issue, concerns, or damage arising from the content of the video. Under no circumstances this channel be responsible or liable in any way for any content, including but not limited to, any errors or omissions in the content, any loss, any damage of any kind incurred as a result of any content communicated in this video, whether by this channel or a third party. In no event shall this channel be liable for any special indirect or consequential damages of any damages whatsoever resulting from the content of the channel.