What is IDO1? скачать в хорошем качестве

What is IDO1?

This video by MTHFR Support™ discusses the importance of the gene IDO1. The pathways for IDO1 are amino acid degradation, L-tryptophan degradation via kynurenine pathway and L-kynurenine from L-tryptophan. When T cells are deprived of tryptophan, they arrest at a mid-G1 phase of the cell cycle. Restoring tryptophan does not restore the activation process, which requires a second round of T cell receptor signaling along with tryptophan. The biological processes for ID01 are cellular nitrogen compound metabolic process, female pregnancy, multicellular organismal response to stress, negative regulation of T-cell apoptotic process. IDO activity in tumor cells may act to impair antitumor responses. Human tumors constitutively expresses IDO. The catalytic activity for IDO1 is D-tryptophan plus O2, which yields informal D-kynurenine and L-tryptophan plus O2, which yields informal L-kynurenine. Together, this information has suggested that antigen-presenting cells can employ IDO1 to restrict T cell activation by blocking T cell proliferation due to tryptophan catabolism. IDO1 stands for indolamine 2,3-dioxygenase 1. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to informal kynurenine. IDO activity in tumor cells may act to impair antitumor responses. Human tumors constitutively express IDO. as Together, this information has suggested that antigen-presenting cells can employ IDO1 to restrict T cell activation by blocking T cell proliferation due to tryptophan catabolism. Speak with a practitioner who understands epigenetics and Nutrigenomics at www.MTHFRSupport.org if you are concerned about IDO1.