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Types of Mutations (Point Mutations and Frameshift Mutations) || Mutations In Genetics

Mutations and Types of mutations - This is the video on mutations, causes of mutations, types of mutations (Point mutation and Frameshift mutation) with NEET PG MCQs. Definition of mutations - 00:21 minutes Mutagens and Mutagenesis - 00:54 minutes Causes of mutations - 01:27 minutes Types of mutation - 02:27 minutes Base substitution or Point Mutation - 03:29 minutes Transition mutation and Transversion mutation - 04:13 minutes Silent Mutation - 05:01 minutes Missense mutation - 05:34 minutes Acceptable Missense mutation - 06:17 minutes Partially Acceptable Missense mutation - 06:54 minutes Unacceptable Missense mutation - 07:55 minutes Nonsense mutations - 08:47 minutes Frameshift Mutation - 10:17 minutes Point Mutation and Frameshift Mutation - 11:27 minutes NEET PG Biochemistry MCQs - 13:05 minutes #mutations #Genetics #molecularbiology #NEET PG #biochemistry Mutation results when changes occur in the nucleotide sequence of a DNA. The term mutation refers to the permanent changes in the DNA sequence. Mutations in germ cells are transmitted to the next progeny and may give rise to inherited diseases. Mutations in somatic cells are not transmitted to the progeny but are important in the causation of cancers and some congenital malfunctions. Mutagens and Mutagenesis Any agent which will increase DNA damage or cell proliferation can cause increased rate of mutations also. Such substances are called mutagens. X-ray, gamma-ray, UV ray, acridine orange, etc. are well known mutagens. The rate of mutation is proportional to the dose of irradiation. Causes of Mutations Errors in replication, If a mismatch base pair is not corrected during proofreading and post replication repair system. Error due to recombination events. Spontaneous change in DNA, e.g. deamination of cytosine to uracil or spontaneous depurination. Environmental factors like chemical mutagens and irradiations, e.g. UV light or ionizing radiation can alter the structure of DNA.