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Professor Reinoud Knops presents an in-depth analysis of the PRAETORIAN trial, comparing the EMBLEM™ S-ICD (Subcutaneous Implantable Cardioverter-Defibrillator) versus transvenous Implantable Cardioverter Defibrillators (TV-ICDs) in patients requiring ICD therapy This trial, involving 849 patients across 39 centers in Europe and the U.S., is the first, randomized, head-to-head trial that compares performance of S-ICD and TV-ICD devices. Over a median follow-up of 48-months, the trial concluded that that S-ICD devices are non-inferior to TV-ICD's in regards to major ICD-related complications, adverse events, and inappropriate shocks. Safety info: https://bit.ly/3kxVIzq ©2025 Boston Scientific Corporation or its affiliates. All rights reserved. All trademarks are the property of their respective owners. Prior to use, please see the complete “Directions for Use” for more information on Indications, Contraindications, Warnings, Precautions, Adverse Events, and Operator’s Instructions at www.IFU-BSCI.com. Rx only. CRM-900305-AA | CRM-2114615-AA Chapters: 0:00 - Overview of the PRAETORIAN Trial 0:16 - Background: EMBLEM S-ICD vs. Transvenous ICD Therapy 1:08 - Challenges Addressed by S-ICD Technology 1:51 - Hypothesis of the PRAETORIAN Trial 2:23 - Design: Patient Inclusion and Exclusion Criteria 3:15 - Standardized Programming Based on Prepared Trial 3:47 - Data Presentation and Publication Overview 4:01 - Baseline Characteristics: Conventional ICD Population 4:41 - Primary Endpoint: ICD Trouble Non-Inferiority 5:23 - Device-Related Complications and Inappropriate Shock Rates 6:53 - Causes of Inappropriate Shocks in S-ICD vs. Transvenous ICD 7:28 - Complications: Infections, Bleedings, and Lead-Related Issues 8:59 - Mortality Analysis: Cardiac vs. Non-Cardiovascular Deaths 9:45 - Appropriate Shock Rate and Lack of ATP Capability in S-ICD 11:15 - Procedural Characteristics: Physician Experience and Procedure Duration 12:16 - Crossovers: Pacing Needs and Device Changes 13:08 - Limitations: Follow-Up Duration and Implant Experience 13:43 - Conclusion: S-ICD Non-Inferior for ICD Adverse Events 14:42 - Discussion: Patient Selection for S-ICD and Secondary Prevention 17:03 - Concerns: Lack of ATP and Bradycardia Function in S-ICD 18:45 - Selection Criteria: Identifying Suitable Candidates for S-ICD 19:37 - Future Analyses and Follow-Up Studies for PRAETORIAN Trial