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This is an 8-minute, comprehensive review of the major side effects of tricyclic antidepressants (such as amitriptyline, nortriptyline, imipramine, desipramine, clomipramine and doxepin), including anticholinergic effects, as well as a review of the absolute and relative contraindications to using these medications due to their toxic and potentially fatal consequences. A few less common and lesser known side effects are also briefly mentioned. It is worth noting here that amitriptyline is the most highly anticholinergic of these medicines, while desipramine is the least. The risk of serotonin syndrome is greatest with clomipramine and imipramine (in combination with other, highly serotonergic agents, such as the MAOIs), while nortriptyline and despiramine are SNRIs with negligible serotonin reuptake inhibitory properties.