FFP EP. 12 | From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap скачать в хорошем качестве

FFP EP. 12 | From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap

After a wild week covering all three 2025 Nobel Prizes, Lester and Krishna look back on how From First Principles started — from their Princeton days to building an “ESPN for Science.” They revisit highlights from this year’s Medicine, Physics, and Chemistry Prizes and talk about why funding, immigration, and fundamental research matter for the future of American science. Quick note: this week’s episode is in vertical format because of a technical hiccup during recording — back to widescreen next week! Summary • Origin Story — How two friends from Princeton (physics + arts program) built FFP and why their immigrant families and science-driven upbringings shaped the show. • The Mission — Building an “ESPN for Science” that treats scientists like athletes and research like sport. • Nobel Recap — Quick follow-ups on Medicine (Tregs and non-immune roles), Physics (macroscopic quantum tunneling and the quantum supremacy debate), and Chemistry (MOFs and industrial scaling). • Funding + Immigration Crisis — Why cutbacks to NSF and DOE grants threaten U.S. science leadership and how immigrant researchers have defined American innovation. Chapters 00:00 Intro — Wrapping up Nobel Week 00:46 Reflections on the 2025 Nobel coverage 01:32 How this show started — the FFP origin story 03:28 Princeton years and early collaborations 05:10 Immigrant families, curiosity, and science households 07:22 Krishna’s path from physics to neuroscience 09:36 Early podcast experiments and the idea behind FFP 11:24 Building an “ESPN for Science” — treating research like sport 13:23 Sponsor — Standard Model Beverages (Galileo can, Dirac logo) 14:29 Alcohol license story and logo easter egg 14:46 Back to the show — housekeeping wrapped 15:16 Nobel Week recap overview — why it mattered 16:36 Medicine Prize — FOXP3 and immune self-control 17:08 Tregs and the 2001/2003 FOXP3 papers 19:20 Physics Prize — Macroscopic quantum tunneling explained 24:25 Berkeley lineage — Clarke, Devoret & Martinis 25:08 Feynman’s “simulate nature” vision and artificial atoms 26:03 What macroscopic really means in quantum physics 26:52 Why quantum devices matter beyond computing 28:15 Chemistry Prize — Metal–Organic Frameworks (MOFs) 30:40 MOF applications: CO₂ capture, water harvesting, hydrogen storage 33:12 How chemistry closed the loop on Nobel Week 35:28 U.S. funding and research investment concerns 37:04 Immigration and the global flow of scientists 39:50 Why fundamental science still matters 41:33 Reflections — what makes good science storytelling 43:11 Behind the scenes — recording chaos & editing rituals 45:27 What’s next for FFP and future coverage 47:04 Thank you to listeners & closing thoughts Show Notes Nobel Prize Press Releases (2025 Medicine, Physics, Chemistry) • https://www.nobelprize.org/prizes/med... • https://www.nobelprize.org/prizes/phy... • https://www.nobelprize.org/prizes/che... Nature Genetics (2001) — FOXP3 mutation papers • https://www.nature.com/articles/ng010... Science (2003) — T-cell function study • https://www.science.org/doi/abs/10.11... Nature (1999) — MOF-5 Discovery (Omar Yaghi et al.) • https://www.nature.com/articles/378703a0 Science (2003) — Reticular Chemistry Foundations • https://pubmed.ncbi.nlm.nih.gov/12802... Google Quantum AI Lab — Nature (2019) Quantum Supremacy Paper • https://www.nature.com/articles/s4158...