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Endotoxemia happens when toxic byproducts from harmful gut bacteria escape through a leaky gut wall into the bloodstream. Here, they trigger significant inflammation throughout the body. Endotoxemia is linked with major depressive disorder, autoimmunity, joint disease, skin problems, and aging poorly. In fact, what people who live to 100 years have in common is low levels of endotoxemia. Research also shows people with endotoxemia have a lower chance of surviving a critical illness or sepsis which is a leaky gut's worst outcome. In this talk, Dr. Kharrazian talks about the factors that cause endotoxemia, why it is considered the most severe form of leaky gut, and strategies for recovery. Chapters 0:00 Introduction 2:58 Leaky gut 4:05 Things to understand about people with leaky gut 6:00 Important concepts to understand about people with leaky gut 7:50 What is endotoxemia? 9:48 Dysbiosis 11:00 Systematic endotoxemia 13:15 Tolerance receptors 13:59 What happens to people with leaky gut 15:30 Effective tests for leaky gut 18:29 Major depressions of endotoxemia 19:15 Mechanisms of endotoxemia 21:20 Key things that happen with endotoxemia 23:25 List of conditions lined to LPS 24:15 Different leaky guts 24:58 How do you fix leaky gut 26:55 What's not gonna fix leaky gut 28:30 Q&A session