Pathogenesis mechanisms of bleeding diathesis due to liver disease (How it causes Bleeding) скачать в хорошем качестве

Pathogenesis mechanisms of bleeding diathesis due to liver disease (How it causes Bleeding)

Bleeding diathesis due to liver disease occurs because the liver plays a central role in blood clotting. Here are the key pathogenesis mechanisms behind this condition: Reduced Production of Clotting Factors – The liver synthesizes most coagulation factors (e.g., Factors I, II, V, VII, IX, X). Liver dysfunction leads to deficiencies, increasing bleeding risk. Thrombocytopenia (Low Platelet Count) – Liver disease can cause splenomegaly (enlarged spleen), which traps platelets, reducing their availability for clotting. Impaired Platelet Function – Even when platelet count is normal, platelet dysfunction occurs due to metabolic disturbances in liver disease. Disseminated Intravascular Coagulation (DIC) – Severe liver disease can trigger DIC, where clotting factors are consumed, leading to uncontrolled bleeding. Vitamin K Deficiency – The liver processes Vitamin K, which is essential for clotting factor activation. Liver disease can impair Vitamin K metabolism, worsening bleeding tendencies. Hyperfibrinolysis – The liver regulates fibrinolysis, the process that breaks down clots. Liver dysfunction can lead to excessive fibrinolysis, preventing stable clot formation. #liverdisease