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This sqadia.com medical video lecture is all about Barrett’s esophagus. In this V learning lecture, pathogenesis, epidemiology, and endoscopic comparison of the normal esophagus and Barrett’s esophagus are discussed in conjunction with complications, molecular biology of neoplasia, and treatment. ▬ 📌 Chapters 0:00 Medicine, Gastroenterology 0:22 Barrett's Esophagus 0:51 Physiological Abnormalities 3:22 Barrett's Metaplasia 6:31 Epithelial cells ▬ 📌 Pathogenesis Several physiological abnormalities such as extreme hypotension of the lower esophageal sphincter, ineffective esophageal motility, and dudenogastric reflux are conversed about initially along with their potential consequences. After that genes involved in Barrett’s metaplasia are pursued. Moreover, the characteristics of Barrett’s epithelial cells are presented. ▬ 📌 Epidemiology Barrett’s esophagus is diagnosed in 55-year-old people. Epidemiologically, it is prevalent between 1.6% and 6.8%, and uncommon in Asian populations. Then Dr. Hamna Iftikhar talks about the risk of cancer in patients with non-dysplastic Barrett’s esophagus. Subsequently, the protective role of Helicobacter Pylori infection is discussed. ▬ 📌 Endoscopy and Biopsy At first, the medical practitioner delineates the endoscopic comparison of the normal esophagus and Barrett’s esophagus. Following this, endoscopy with biopsy is considered. Intestinal type and Gastric cardiac type are the two histological types of epithelium discussed here. Then classification according to segments is given which encompasses long segment, short segment, and Prague C and M criteria. ▬ 📌 Complications At the beginning of this section, the molecular biology of neoplasia is elaborated. Then light is shed on aneuploidy which is a biomarker for neoplastic progression in Barrett’s esophagus. Dr. Hamna Iftikhar also explains how aneuploidy can be detected. Subsequently, dysplasia is discussed. Lastly, the incidence of esophageal cancer is reported. ▬ 📌 Treatment In the beginning, treatment of GERD is discussed. Then information about aspirin and NSAIDs is given on how these drugs are protective against esophageal adenocarcinoma. Conclusively, the focus is shifted toward the treatment of mucosal neoplasia which includes endoscopic ablative therapy, endoscopic mucosal resection, endoscopic eradication therapy, and esophagectomy. ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More