Improving Cartilage Phenotype from Differentiated Pericytes скачать в хорошем качестве

Improving Cartilage Phenotype from Differentiated Pericytes

The study compares phenotype characteristics between pericytes, obtained from human adipose tissue, differentiated in 3D culture using Biogelx hydrogel technology and with the more widely used chemical induced method for chondrogenesis. In Biogelx gels tuned to a stiffness similar to that reported for chondrons (15.5 kPa), they found that the phenotypic characteristics of chondrocytes cultured in Biogelx hydrogels were more desirable than those achieved using chemical induction methods. These include significantly higher levels of type II collagen (over type X collagen) being observed when pericytes undergo chondrogenesis in the Biogelx hydrogel, and that there is also a balanced expression of collagen relative to aggrecan production, a feature which was biased toward collagen production when cells were cultured with induction media. Case study is available here: https://www.biogelx.com/case_study/im...