Disorders of Renal Function | Chapter 33 – Porth’s Pathophysiology (5th) скачать в хорошем качестве

Disorders of Renal Function | Chapter 33 – Porth’s Pathophysiology (5th)

The comprehensive overview of kidney function disorders begins by detailing developmental and genetic abnormalities such as renal agenesis, hypoplasia, and dysplasia, including the various forms of inherited cystic kidney diseases like Autosomal Dominant and Recessive Polycystic Kidney Disease (ADPKD and ARPKD). The chapter then pivots to obstructive uropathies, focusing on the destructive effects of urine stasis and progressive dilation, particularly hydronephrosis, and thoroughly examining the common etiology of renal calculi (kidney stones), including the roles of urine supersaturation, crystal nucleation, and specific stone compositions such as calcium, struvite, uric acid, and cystine. A significant section addresses Urinary Tract Infections (UTIs), examining host defense mechanisms like the washout phenomenon against pathogen virulence factors, noting the critical role of obstruction and vesicoureteral reflux, and highlighting unique risks and clinical manifestations in special populations, including pregnant women, children, and older adults. Moving inward to the filtering structures, glomerular diseases are categorized into clinical syndromes—the nephritic syndromes (characterized by inflammation, hematuria, and decreased GFR) and the nephrotic syndrome (marked by massive proteinuria and generalized edema)—as well as complications arising from systemic conditions such as Systemic Lupus Erythematosus (SLE), diabetes mellitus (diabetic glomerulosclerosis), and hypertension (nephrosclerosis). Finally, the chapter concludes by covering tubulointerstitial diseases, specifically Proximal and Distal Renal Tubular Acidosis (RTA), acute and chronic pyelonephritis, drug-related nephropathies, and a review of malignant tumors, including Wilms tumor in children and adult renal cell carcinoma, discussing their respective etiologies and treatment modalities. 📘 Read full blog summaries for every chapter: https://lastminutelecture.com 📘 Have a book recommendation? Submit your suggestion here: https://forms.gle/y7vQQ6WHoNgKeJmh8 Thank you for being a part of our little Last Minute Lecture family! ⚠️ Disclaimer: These summaries are created for educational and entertainment purposes only. They provide transformative commentary and paraphrased overviews to help students understand key ideas from the referenced textbooks. Last Minute Lecture is not affiliated with, sponsored by, or endorsed by any textbook publisher or author. All textbook titles, names, and cover images—when shown—are used under nominative fair use solely for identification of the work being discussed. Some portions of the writing and narration are generated with AI-assisted tools to enhance accessibility and consistency. While every effort has been made to ensure accuracy, these materials are intended to supplement—not replace—official course readings, lectures, or professional study resources. Always refer to the original textbook and instructor guidance for complete and authoritative information.