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Plants are under a variety of constant stress like heat, dehydration and UV exposure. At times, they are also subject to other abiotic stress such as salinity. But, importantly, they are constantly under biotic stresses such as pathogenic attack. How do plants deal with them? How can computational studies of proteins, such as transcription factors, implicated in plant stress be helpful? We will first describe our development of Hidden Markov Models and search algorithm to identify transcription factor binding sites upstream of stress-upregulated genes in plants. This survey is valuable since we can begin to understand the functional variety of stress-upregulated genes and the network of regulatory interactions. Next, we will present our collaboration with Atle Bones lab, where combined stresses are placed on the popular model organism, Arabidopsis thaliana, to gain insights into these regulations. Finally, we will present our three-dimensional modeling and molecular dynamics to provide structural rationale for a set of sodium transporters within rice varieties under saline-stress by comparing with their counterparts which are not salt-resilient. Watch our first talk in medicinal plants and collaborations theme of capstalks series that celebrates 25 years of the CAPS lab at NCBS, led by Prof. Sowdhamini. ##bioinformatics #research #science #academia #CAPS