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Heme Catabolism And Transport Of Bilirubin : Medical Biochemistry by Dr Prakash Mungli

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   Hello Everyone, To Access, The Notes Of this Session, Join Our Telegram Channel. We Will Post Notes After the session JOIN HERE:- https://t.me/bhanuprakashdr Subscribe To My Mailing List:- https://linktr.ee/DrGBhanuprakash RBCs undergo a breakdown process after their normal life cycle and yield heme, which is further broken down into unconjugated bilirubin. Unconjugated bilirubin is a lipid-soluble molecule that is insoluble in aqueous solutions and is therefore bound to albumin for transport to the liver, where it is ultimately conjugated by UDP-glucuronyl-transferase. Conditions that cause an unconjugated hyperbilirubinemia are either due to an increased breakdown of RBCs or a decreased conjugation of bilirubin. Conditions that cause a conjugated hyperbilirubinemia are either due to a deficiency of a canalicular membrane transporter or a blockage of the bile ducts. Unconjugated hyperbilirubinemia will cause jaundice (yellow pigmentation of the skin) whereas conjugated hyperbilirubinemia will cause pale stools and dark urine. #hememetabolism #hemecatabolism #jaundice #jaundicetreatment #bilirubin #bilirubinmetabolism #fmgejan2023 #mbbslectures #nationalexitexam #usmlepreparation #nationalexittest #neetpg #usmlestep1 #fmge #usmle #medicalstudent #medicalbiochemistry #medicaleducation #medicalstudents #medicalcollege #medicalstudentlife