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Watch the Full Video at https://www.jove.com/v/53182/generati.... Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells - a 2 minute Preview of the Experimental Protocol Estrelania S. Williams, Veronica Rodriguez-Bravo, Uma Chippada-Venkata, Janis De Ia Iglesia-Vicente, Yixuan Gong, Matthew Galsky, William Oh, Carlos Cordon-Cardo, Josep Domingo-Domenech Icahn School of Medicine at Mount Sinai, Department of Pathology, Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai, Department of Hematology/Oncology, Tisch Cancer Institute; Memorial Sloan-Kettering Cancer Center, Molecular Biology Program; This manuscript details a method used to generate prostate cancer patient derived xenografts (PDXs) from circulating tumor cells (CTCs). The generation of PDX models from CTCs provides an alternative experimental model to study prostate cancer; the most commonly diagnosed tumor and a frequent cause of death from cancer in men. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments