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Creatine and Mental Health

00:00:00 - Introduction: Creatine and Depression Research Overview 00:02:11 - CBT with Creatine for Depression 00:03:38 - Dose Discussions: 5g vs 10g of Creatine 00:05:10 - Brain Uptake of Creatine and Sleep Deprivation Studies 00:07:18 - Side Effects and Safety Profile of Creatine 00:08:10 - Significant Symptom Reduction: PHQ-9 Results 00:09:51 - Practical Tips: How to Take Creatine 00:11:14 - No Conflicts of Interest: Big Creatine Isn’t a Thing 00:12:12 - Creatine Augmentation with SSRIs 00:13:40 - Faster Response Times and Effect Sizes with Creatine 00:16:49 - Dropout Rates and Patient Adherence Issues 00:19:15 - Creatine vs Traditional Antidepressants: Effect Size Comparison 00:20:46 - Creatine in Bipolar Depression 00:22:08 - Mania Switch Risks: Considerations for Bipolar Patients 00:24:34 - Creatine for Adolescents with Depression 00:27:10 - Brain Creatine Increases Shown on Imaging 00:27:59 - Creatine Monotherapy Study 00:29:52 - Dietary Creatine Intake and Depression Risk 00:31:32 - Creatine as a Potential Preventative for Depression 00:34:52 - Low Brain Creatine and Depression Severity 00:37:10 - Importance and Limitations of Imaging Studies 00:41:11 - Creatine in Dual Diagnosis Patients 00:44:57 - Dose-Response Study in Adolescents 00:50:52 - Mechanism: How Creatine Supports Brain Energy 00:55:07 - Stress, Sleep Deprivation, and the Need for Brain Reserves 01:00:27 - Combining Creatine with Exercise for Maximum Benefit 01:03:48 - Creatine Enhances Mitochondrial Function 01:07:46 - Cerebral Energy Boost: Han and Takashima Study 01:10:45 - Creatine’s Safety Regarding Kidney Function 01:15:03 - Sleep Deprivation Studies: Executive Function Preserved 01:21:17 - Final Reflections: Future of Creatine Research Discover how creatine supplementation could significantly benefit mental health and cognitive performance in this insightful discussion. Dr. David Puder is joined by Nicholas Fabiano, MD, Brandon Luu, MD, Joshua Mangunsong, MS3, and Liam Browning, MS4, who unpack recent scientific findings on creatine’s role in reducing symptoms of depression, anxiety, and bipolar disorder, and improving cognitive abilities such as memory, logic, and processing speed. They highlight evidence from clinical studies, discuss optimal dosage recommendations, explore how creatine supports brain metabolism, and address common safety concerns. Ideal for anyone interested in innovative, evidence-based psychiatric treatments. Subscribe for more episodes exploring advancements in mental health. Link to Blog: https://www.psychiatrypodcast.com/psy... By listening to this episode, you can earn 1.5 Psychiatry CME Credits: https://www.psychiatrypodcast.com/cme...