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Heart disease is the leading cause of death in women. But what if the risk factors we focus on are only part of the story? In this groundbreaking keynote from the 13th Annual Women’s Heart Symposium, renowned cardiologist Dr. Sanjay Rajagopalan challenges conventional cardiovascular risk models and introduces a transformative framework centered on environmental exposure, toxicology, and exposomics. From wildfire smoke and air pollution to PFAS, microplastics, endocrine disruptors, and chronic low-dose chemical exposure, this talk explores how cumulative environmental factors silently shape cardiovascular outcomes across a woman’s lifespan. Dr. Rajagopalan explains how pollutants trigger inflammation, oxidative stress, endothelial dysfunction, plaque instability, arrhythmias, heart failure, and ischemic heart disease and why emerging data suggests that certain environmental exposures may be more cardiotoxic than previously understood. This keynote moves beyond cholesterol and blood pressure alone to examine lifetime exposure burden, gene-environment interactions, and the urgent need for a more holistic, systems-based approach to preventive cardiology. For clinicians, this session offers insight into integrating environmental risk assessment into patient counseling, screening, and prevention strategies. For patients and community members, it provides actionable awareness around reducing exposure, building resilience, and advocating for heart-healthy environments. Presented by Have a Heart, Save a Heart during Women’s Heart Month, this lecture titled "Toxic Exposures to Transformative Exposomics: Towards Holistic Frameworks to Understand Cardiovascular Health" reflects our mission to translate leading cardiovascular research into accessible education that empowers women, families, and medical professionals alike. Key Topics Covered: • Environmental toxins and cardiovascular disease • Exposomics and cumulative risk modeling • Wildfire smoke and PM2.5 cardiovascular mortality • PFAS and cholesterol dysregulation • Microplastics and vascular inflammation • Women’s heart health disparities • Preventive cardiology and risk mitigation • Public health, policy, and environmental justice About the Women’s Heart Symposium: The Women’s Heart Symposium is an annual convening of leading cardiologists, researchers, and public health experts focused on advancing women’s cardiovascular health through science, education, and community engagement. Learn more about upcoming events, the 33% Pledge, and HeartSource educational resources at Have a Heart, Save a Heart's website! If you care about women’s health, environmental health, preventive cardiology, public health policy, or the future of cardiovascular medicine, this is a conversation you cannot afford to miss. Subscribe for more expert lectures, patient education resources, and in-depth conversations on women’s heart disease prevention. #WomensHeartHealth #Cardiology #PreventiveCardiology #EnvironmentalToxins #Exposomics #WildfireSmoke #PFAS #Microplastics #HeartDiseasePrevention #EnvironmentalHealth #CardiovascularResearch #PublicHealth #HaveAHeartSaveAHeart #WomensHeartSymposium