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Watch the Full Video at https://www.jove.com/v/52152/complete.... Complete Thymectomy in Adult Rats with Non-invasive Endotracheal Intubation - a 2 minute Preview of the Experimental Protocol Victoria R. Rendell, Charles Giamberardino, Jie Li, M. Louise Markert, Todd V. Brennan Duke University Medical Center, Department of Surgery; Duke University Medical Center, Department of Pediatrics; Duke University Medical Center, Department of Immunology; Rodent thymectomy is a valuable technique in immunological research. Here, a protocol for complete thymectomy in adult rats using a mini-sternotomy along with non-invasive intubation and positive pressure ventilation to minimize perioperative morbidity and mortality is described. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments